Was looking for this particular item for grandad.. they happen to have free full size sample offer at the moment. Hope this helps some others experiencing joint pain.
Flexiseq Joint Lubrication Gel 50g Free Sample Worth $49.95
1090
Related Stores
closed Comments
Apparently… here is the same item listed http://www.chemistwarehouse.com.au/search?searchtext=Flexise…
Lub>?
Hope this helps some others experiencing joint pain.
And your……………
Thank you, got some for my old man.
got some for my old fella
(FTFY)
Hands up if you misread that brand as "Flexisex"
Lubrication was enough
and then "particular item for grandad"
I wonder how many people went through this exact some mental process.
Is this as good as Flexall?
Since it is $50 I thought it was 50kg, wow that's expensive!
Thanks OP. You had me at lubrication.
700clicks in 40mins! This is getting Ozbargained for sure!
Mission Accomplished:
Thanks for ordering Flexiseq
The demand for Flexiseq Joint Lubrication Gel 50g has been overwhelming.
Is the penis a joint?
No it is a knob
That's expensive lube.
Please only get this if you really intend on using it. See it too often of people just claiming it, just because it there!
The damage has already been done 😕.
881 clicks
giving it a try..thanks for the link
Looks and sounds suss as. Even the http://www.flexiseq.com.au/in-the-media/ page is full of bs 'news stories. Only saving grace is the fact that it's stocked at CW but still looks like a snake oil product to me! Ah well, free is FREE! Cheers OP.
FLEXISEQ is a gel that uses Sequessome Technology to delivery tiny biolubricating vesicles (spheres) through the skin and directly into joints to coat the surface of the cartilage
That sounds like science, it must work!
Don't you believe in sequessomology? Surely this is made by earnest bespectacled white-coated "top" scientists holding clipboards.
Well I never
Garbage vague opinion-based study at best in which patients were simply asked for their opinions, of which this product performed 4%-8% better vs another product that costs a tiny fraction of the price. No allowances taken into consideration for measurements of pain for each patient, nor was there so much as an observation of any improved movement of ability with the effected area being treated either. In fact the only mention of any observation of the actual effect of the product was that numerous patients had adverse skin reactions.
@infinite:
so you read the entire paper, or are working from ignorance again from the abstract.
I guess you are too ill inclined to facts to even notice you made identical comments on completely different articles….
http://www.jrheum.org/content/40/10/1742.abstract@mycosys: Both articles reference the exact same bogus company-supported & paid for studies, conducted by company employees. The first article discusses a study that is nothing more than a review of the delivery method of the cream, which quite shockingly concludes that the cream when rubbed against your skin, is absorbed into your body.
It's standard stock stuff where companies like this conduct "studies" into basic functions of the product, simply so they can advertise that it's a "proven" product. But they study everything about the product other than it's actual purpose, in any real detail. Even in their preliminary studies, they can't even actually explain parts of how the product is even actually delivered. They literally don't even understand how the product functions at it's base level, while simultaneously advertising it's "clinically proven benefits".
Both articles reference the exact same bogus company-supported & paid for studies, conducted by company employees.
Yup. Some of these guys are naively labouring under the misapprehension that getting your colleagues & lackeys to sign off on your bullshit constitutes "peer review". ;)
IME, not one of these OTC topical pain relief remedies is worth a pinch of poop in the real world…and all the cherrypicked quasi-qualitative studies in the world won't change the fact that they're placebos at best, but most likely pure snake oil.
Was it the fact that it's called lubrication gel and that it claims that it provides lubricant for your joints and you drink it?
you dont drink it, it is topical
Just a friendly reminder that this is not a medicine, nor does it have any proven clinical evidence of being of any benefit at all. It's a standard stock premium sales item that pharmacists try and up-sell to people (mostly old people), ironically, who are too stingy to pay for a doctors visit. So instead of getting a cheap alternative that's equally as useless or something clinically proven to actually work via the doctors advice, they end up buying this obscenely over-priced snake oil from their local pharmacist.
Edit: I gave the deal a positive by mistake >.<
The closest thing to a positive about this deal would be it's scam-alert status.
You're forgetting the clinical grade placebo effect…
helps to know what you are talking about - significantly more effective than placebo or topical ketoprofen anti-inflammatory in randomised double blind phase 3 trial n=550
http://www.jrheum.org/content/40/10/1742.abstractGarbage vague opinion-based study at best in which patients were simply asked for their opinions, of which this product performed 4%-8% better vs another product that costs a tiny fraction of the price. No allowances taken into consideration for measurements of pain for each patient, nor was there so much as an observation of any improved movement of ability with the effected area being treated either. In fact the only mention of any observation of the actual effect of the product was that numerous patients had adverse skin reactions.
Bummer! I was going to get it for Dad who has really severe osteo arthritis :(
Can't hurt but possibly won't ease pain much.
Based on what?
Garbage vague opinion-based study at best in which patients were simply asked for their opinions, of which this product performed 4%-8% better vs another product that costs a tiny fraction of the price. No allowances taken into consideration for measurements of pain for each patient, nor was there so much as an observation of any improved movement of ability with the effected area being treated either. In fact the only mention of any observation of the actual effect of the product was that numerous patients had adverse skin reactions.
Worth mentioning that both authors on this paper are affiliated with Pro Bono Bio, the company that produces Flexiseq; that M. Rother (primary author) is a paid consultant of Pro Bono Bio; that the study was funded by IDEA AG, for whom M. Rother is employed. The study compares IDEA-033 Ketoprofen Gel (a 'Transfersome' drug-delivery mechanism; Transfersome being a trademarked term for a phospholipid vesicle that may carry a drug - ketoprofen - through the skin and into cellular cytoplasm) vs. drug-free TDT 064 (the Flexiseq 'Sequessome', which is a phospholipid vesicle that passes through the skin and is reported to aggregate on cartilage surfaces. Their mechanism of action is not known, but the proposed hypothesis is "some form of biolubrication").
I'm not knocking the product necessarily but 'very promising' is perhaps an over exaggeration when the only studies done in to TDT-064 involve some level author/editor affiliation with Pro Bono Bio. Just take it with a grain of salt. Here are the facts:
2007: M. Rother, et al., publish paper in Annals of Rheum Dis that show IDEA-033 is 'comparably' effective compared to oral celecoxib in terms of pain management and improving physical functionality related to osteoarthritis of the knee. Results indicate it is, on average, less effective than celecoxib in both areas; citation
2013: M. Rother & P. Conoghan publish paper in J Rheum showing TDT-064 more effective than IDEA-033 in treatment of osteoarthritis; citation
2013: W. Kneer, et al., publish paper in J Pain Res showing IDEA-033 is only marginally more effective than TDT-064 in treating osteoarthritis; citation
2013: P. Conoghan, et al., (inc. M. Rother), publish paper in Rheumatology (Oxford) comparing efficacy of ketoprofen vehicle (IDEA-033) vs ketoprofen free vehicle (TDT-064), with results showing IDEA-033 is "not superior to ketoprofen-free vehicle", and both are "superior to oral placebo and non-inferior to celecoxib". Results indicate that while the percentile decrease in WOMAC pain score IS statistically significant between placebo and IDEA-033/TDT-064, the actual 'statistically superior' score was a mean decrease of '-1.9' registered for both IDEA-033 and TDT-064, compared to a mean decrease of '-1.6' seen in placebo groups. For reference, the WOMAC pain subscale is between 0 and 20, and patient baseline mean in this study ranged from 4.7 to 4.8. In other words, a patient who with a pain rating of 4.8 and who received the oral placebo on noted after 12 weeks a pain rating of 3.2. A patient receiving either topical treatments, who went in with a pain rating of 4.8, registered a pain rating of 2.9 after 12 weeks. That's a 0.3 difference between placebo and variable factor, on a 0 - 20 ratings scale, over 12 weeks. (If you study statistics or are at all familiar with the flaws of rating scales, those numbers would probably do your head in). Citation (And be sure to check out the supplementary data, which shows a nice bar graph that indicates very little qualitative difference noted by patients).
2016: EJ. Seidel, et al. (inc. M Rother and I. Rother), publish paper in J Sports Sci comparing efficacy of IDEA-033 and TDT-064, with or without oral ketoprofen, in aiding muscle soreness following exercise. Results showed neither 'ultradeformable phospholipid vesicle', with or without ketoprofen, improved muscle soreness stemming from exercise. Interestingly enough, patients studied showed a higher pain score and longer recovery time when using TDT-064 + oral ketoprofen, the focus of the study, 12-16 hours post exercise. Comparatively, patients who received just the IDEA-033 ketoprofen topical with an oral ketoprofen placebo showed lower levels of pain, and a lower recovery time (high variability, P=0.59, not an accurate comparison). Patients receiving TDT-064 and a placebo, i.e. no ketoprofen at all, also showed comparatively lower pain scores & recovery times (low variability, P=0.02, statistically significant comparison). Citation
As a final remark, I'll address a question that some keen-eyed readers who have made it this far may have; What's this celecobix you mentioned and if it's more effective than any of these topical lotions and gels, why don't people just use that to treat osteoarthritic pain?
Celecobix is a non-steroidal anti-inflammatory drug often used to treat pain associated with osteoarthritis, rheumatoid arthritis. It is about five times as expensive as paracetamol or ibuprofen, equally as effective as both, and the American Heart Association is warning people at risk of heart disease against it due to the risk of it increasing your chances of major cardiovascular problems by 37%.
TL;DR: If you really love your grandparents, buy them a pack of paracetamol.
edit: As an additional, I can't find any evidence to support Flexiseq selling 'Sports' and Flexiseq 'Active' variations of the product - nor can I identify anywhere that outlines the difference between these products. Given the current research I think selling anything other than 'Flexiseq Osetoarthritis' is blatantly misleading.
@infinite: Incorrect - WOMAC scale is the 'gold standard' in terms of pain rating relating to arthritis and if you look for a clinical study in to arthritis treatment, it's likely they all use the WOMAC scale. It is a rating scale based on subscales of variable ranges, e.g. pain ranges from 0 - 20, so of course there is variation between individuals based on their interpretation of that.
No allowances taken into consideration for measurements of pain for each patient, nor was there so much as an observation of any improved movement of ability with the effected area being treated either.
"Both groups reported progressive decreases in pain and improvements in function and stiffness" - article abstract; unless this is countered in the full PDF in any way, which I can't see because it's behind a paywall and I'm not paying for this garbage. But, there literally was.
What the study is actually showing is that IDEA-033 works slightly less effectively than TDT-046. Given that they're effectively the same thing, except IDEA-033 has ketoprofen in it, it's actually a pretty relevant finding. I would also be interested to see how you got the idea that IDEA-033 ('Transfersome') is A) a product that costs a fraction less than Flexiseq, and B) is even available to purchase? Given that it's a trial drug, and all.
Now that I've got all that out of the way - check my other post in reply to Mycosys as to why Flexiseq is actually garbage and you may as well buy ibuprofen.
I'm all for debating research mate, but at least do it properly and don't post an opinion piece ironically criticising other opinions.
@infinite:
Maybe you should actually bother to read the article before commenting? Your comment bears no resemblance to the work.What is that saying about opening your mouth and removing all doubt?
@McManly:
As you and i are both aware ALL pre release drug trials are undertaken under financing from he drug developer, apart form rare cases where national interest directs urgent funding. Why on earth would we pay for companies to bring their new profit sources to market?And the question has never been if you should use paracetamol (which is incidentally less effective than ibuprofen by a long way) but what adjuncts can be used, particularly in patients with compromised renal, hepatic, digestive function etc, patients already on complex medical; regimes and patients with crippling degenerative disease which is responding poorly to conventional treatment. Yes it is obviously early days but the only way the product will show adjunct efficacy is in wide-scale use allowing wide scale research. What has been established is it is safe, simple plant lipids.
Certainly the cost is prohibitive for many, but for those with complex needs it is a hell of a lot better value than most of the adjuncts sold for OA which actually do nothing but line the producers pockets (like glucosamine, chondroitin, msm and a ridiculous number of other alternative crap). At least this has shown efficacy statistically significantly greater than conventional treatment and placebo in double blind randomised peer reviewed testing, something few treatments for OA can say.
@mycosys: You know I had this whole thing written out, and then when I realised exactly how laughable Flexiseq is as a product I decided I've put this much work in to it now, I may as well go the whole hog and put the work toward an actual review of the product and the research that went in to it. Cheers! You got my research juices flowing.
I do want to add that I reject any indication that you and I are on the same wavelength when it comes to how "ALL" drug trials are performed. Drugs that are being pushed through by drug developers before they have even demonstrated efficacy (see: this Q&A breakdown of why Diractin aka IDEA-033, produced by IDEA AG, had its application for approval in Europe withdrawn when they were told they were not going to receive approval). Wait, 'IDEA-033' rings a bell, doesn't it? Isn't it that drug that was comparable in efficacy to TDT-046? Oh wait, it is, and TDT-046 is the name for the placebo involved in that Phase III trial on IDEA-033 which wasn't going to be approved anyway!
@McManly:
So you know better than the Chairman of Eli Lilly who outright states that most drug trials are paid for by the manufacturer hoping to market the drug
http://www.forbes.com/sites/johnlechleiter/2015/07/21/clinic…Or are you just unable to comprehend context in sentence clauses?
nor does it have any proven clinical evidence of being of any benefit at all
Maybe, maybe not
http://www.tandfonline.com/doi/pdf/10.1185/03007995.2013.860…
Funny - the science seems to disagree
http://www.ncbi.nlm.nih.gov/pubmed/24164189
Maybe you should research before making such sweeping proclamations based on ignorance?Garbage vague opinion-based study at best in which patients were simply asked for their opinions, of which this product performed 4%-8% better vs another product that costs a tiny fraction of the price. No allowances taken into consideration for measurements of pain for each patient, nor was there so much as an observation of any improved movement of ability with the effected area being treated either. In fact the only mention of any observation of the actual effect of the product was that numerous patients had adverse skin reactions.
I posted a response above with some actual research if you're interested.
ozbargain has made me person to order now think later whats that for..
wonderful - which means that people in daily agony with moblity impairments will likely miss out so your tube can sit on the shelf.
nice one
Not working for me, shows me $57.95
no longer valid?
And nothing of value was lost.
maybe not for you, but people with OA are crying out for low side effect treatments for a crippling illness. This shows promise as one, as supported by the clinical trials
Finished on 1 Sugust - cams in my email this morning 2 Aug. bugger.
The extra price from $49.95 is P&H charge
Maybe I shouldn't be saying this but I was playing around with the coupon code box and if you type in 'freesample' it still works.
Please only get this if you really need it though.Thank you so much. My sister has knee arthritis and she suffers heaps. Has been taking tablets and applying creams but not always work as they should. Please, use this ONLY if you REALLY need it.
Helps reduce stiffness
make sure washing your hand properly after use and don't mistake it as KY.
If it helps reduce stiffness it may not be the best for bedroom activities!
n=400 non blinded trial …
superior to topical ketoprofen in randomised double blind phase III n=550
http://www.jrheum.org/content/40/10/1742.abstractGarbage vague opinion-based study at best in which patients were simply asked for their opinions, of which this product performed 4%-8% better vs another product that costs a tiny fraction of the price. No allowances taken into consideration for measurements of pain for each patient, nor was there so much as an observation of any improved movement of ability with the effected area being treated either. In fact the only mention of any observation of the actual effect of the product was that numerous patients had adverse skin reactions.
funny - you have never even read the abstaract.
Your opinion is about as useful as your perception - you cant even notice there is more than one journal linked, completely different website and all
@mycosys: Interesting that you're singing the praises of this product, yet haven't pos'd the deal???
@StewBalls:
Im signing the praises of KNOWLEDGE and actuallyt knowing what the heck you ar talking about when commenting om a matter.
If you cant take a couple of minutes to find out whether you are right, then dont bother spreading your ignorance.
These are the same 1D-ten-ts that spread facebook hoaxes and chain emails@mycosys: Wow, such emotion & vitriol over a simple fact, no wonder nobody is taking you seriously here…
@StewBalls:
do you really think i care what a subnormal intelligence with no idea what vitriol is thinks?
They must have put the price up due their demand. Now they are wondering why no one is buying it.
I can't believe in this day & age that people can be fooled by these "Snake-Oil" peddlers.
Firstly: Pain is relative to the individual… What is really painful to some, can be no more than an annoyance to others.
Secondly: Pain is in your head… What happens?
If you stub your toe, a signal (of pain) is sent to your Brain, which then in turn makes you, hop about, swear, rub the affected area, etc…
The way to subdue pain is to make the brain less susceptible to the pain signal effect.
Rubbing cream into the affected part is only a placebo effect. The PAIN signal is coming from the Brain.
Lets put it another way.
If you had a headache you wouldn't rub a cream all over your head, you would take paracetamol (or other drugs) to interrupt the pain signal within your head.
ALL pain is relative, REAL pain (something that SHOULD be extremely painful) doesn't hurt at all.
The brain is a complex organ that is still (largely) unknown. It will shut-down the pain receptors if the injury is extremely dire.
The Brains' pain receptors are natures way of saying: DON'T DO THAT… It is also a fairly good predictor that your not going to die from that stubbed toe…Yes, pain is relative but knowing two people who suffer from severe arthritis, I know their suffering and their pain is real. My Dad cries and cannot sleep ,walk or fuction at times from the pain, I would hate to live like that :( . I should mention he's normally one tough cookie.
The reality is that people in acute or chronic pain situations can be desperate at times to relieve that pain.
In those instances the pain isn't protective or helpful, but highly debilitating.Pain can be avoided by blocking the appropriate receptors yes, but if the cause for the pain can be avoided (e.g bone on bone contact due to cartilage having worn down) then there is nothing wrong with applying something 'if it is proven to work'.
As itajac says you can't comprehend how 'chronic' pain affects someone without being there first hand
Arggh… your smart arse comments really make me fuming!!!
You are bloody ignorant fool, probably 20 years old and never really suffered from any chronic pain. BTW when I was bellow 30 I did not have any chronic or joint pain either.
Few years ago I had a left shoulder injury that ended up in bursitis and after months of physio, non steroid anti inflammatory drugs (ibuprofen, diclofenac) I reached the limits of my recovery. At that point I could not touch between my shoulder blades using my left arm, I could not reach for the seat belt in the car, lifting above eye level was accompanied with teeth clenching and feeling that my eyes are popping out. Chronic pain is terrible debilitating condition so do not pour these "wisdom pearls" that people suffer pain because they chose to, their brain could elect at any time to feel the pain to to stop punishing them! You bloody, bloody fool!!!
BTW my condition improved after getting cortisone injection in my shoulder that reduced bursa swelling, but you probably think it was a placebo, or maybe a drug that shut of the part of my brain with pain receptors from the left shoulder area.
What a complete load of ignorant crap contradicted by every reliable piece of research in the last 40 years. Why dont you read the links which utterly contradict you.
OA pain is not neuropathic - it does not originate in the nerves. You reduce it best by PREVENTING the pain, not interrupting it. This is what anti-inflammatories do. The research appears to indicate this product does indeed penetrate (as do topical anti inflammatories) and lines the synovial gap, as cartilage would in a normal person were it not worn out as in OA, preventing bone on bone and damaged soft tissue to damage soft tissue contact, hence preventing the CAUSE of the pain.
Try to have a clue what you are talking about when you commentOh my where do I start….
If you stub your toe, a signal (of pain) is sent to your Brain, which then in turn makes you, hop about, swear, rub the affected area, etc…
That's false, Once your body detects pain, the signals travel up to your spinal cord, then it sends down a reflex to remove your hand/feet from the source of pain.
The signal then travels up to your brain for processing and then sends signal back down to the site of the pain to release chemicals called prostaglandins. NOW nerve endings are VERY sensitive to this (as our bodies way to tell us to stop using that part of the body)THIS IS THE PAIN WE FEEL…
NOW drugs such as paracetamol stop the production of precursor chemicals that make prostaglandins. others compete for the receptors of these nerves to block the signals.
Creams such as these effectivly act in a similar way HOWEVER, the act locally and therefore provide faster relief from the pain
Rubbing cream into the affected part is only a placebo effect. The PAIN signal is coming from the Brain.
Lets put it another way.Answered above…pain is coming FROM THE NERVE where the injury is AND THIS SIGNAL is detected by the brain
If you had a headache you wouldn't rub a cream all over your head, you would take paracetamol (or other drugs) to interrupt the pain signal within your head.
Answered above (Do you have any scientific background or just pulling these info from your A**!)
To a final note, yes pain is Relative and each person has a level of threshold, however (although i haven't researched this) but I assume that this threshold would be very similar when comparing a large population size.
Fore example, I have been able to train myself to "remove the pain" by mentally repeating that "i have no pain" while looking/thinking about that site of pain. I found this effective in accute headaches and some joint pains BUT is ineffective when I get migrains/sever joint pain3rd year physiology major
Damn, I missed it again. Wanted to use it on my bike.
Has anyone received their lube yet?
Nope
No, and I won't be holding my breath.
Start holding it. Mine turned up today in Brisbane.
Nice to be proved wrong. Mine arrived today.
emailed them got this reply:
My receptionist says she will complete this task in a few days’ time - as she has been inundated with positive emails from consumers.
:-0 Surely there isn't one person sending out this stuff? It sounds like a backyard operation.
Got mine today in Sydney.
Also got mine a couple of days ago.
That's a thirsty thumbnail.
Also a 50g sample is worth $49.95???