Swisse High Strength Cranberry 25,000mg 30 Caps $8.75 (Minimum 2) RRP $23.95 with COUPON CODE @ Blackshaws Road Pharmacy [VIC]

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Blackshaws Road Pharmacy

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  menace208 on 15/11/2016 - 15:14

  Free shipping option is not available. Only available option is flat rate shipping for $5

  • 

    AssociatedHugoHugo @ Blackshaws Road Pharmacy on 15/11/2016 - 15:19

    +1

    If you type in the coupon code then the shipping costs should disappear.

    • 

      menace208 on 15/11/2016 - 19:26

      Discount is applied but shipping charge is still flat rate $5

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        AssociatedHugoHugo @ Blackshaws Road Pharmacy on 16/11/2016 - 16:06

        I've just tried in again, and there isn't a shipping charge. And it definitely didn't appear on all the orders that have been placed for it so far either.

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  zliu18 on 15/11/2016 - 15:30

  +1

  It is just 8.99 in CW.

  • 

    AssociatedHugoHugo @ Blackshaws Road Pharmacy on 15/11/2016 - 15:33

    And shipping charges?

  • 

    Darkii on 15/11/2016 - 15:49

    +1

    Still save 24c with this Ozbargain pharmacy, mate.

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      AssociatedBlackshawsRdPharmacy @ Blackshaws Road Pharmacy on 15/11/2016 - 18:04

      Yes, a proud OzBargain community pharmacy.

      • 

        Darkii on 15/11/2016 - 19:47

        +1

        Love your work mate. You would be my local pharm if I were around you.

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  bargaino on 15/11/2016 - 17:29

  Is this the same?

  http://www.allstarhealth.com/en-au/de_p_ref/35901/gsau35901/…

  https://www.efsa.europa.eu/en/efsajournal/pub/3656

  Following an application from Naturex SA, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of France, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related to Pacran® and defence against bacterial pathogens in the lower urinary tract. The food that is the subject of the claim is Pacran®. The Panel considers that the food, Pacran®, which is the subject of the claim is sufficiently characterised in relation to the claimed effect. The Panel considers that defence against bacterial pathogens in the lower urinary tract is a beneficial physiological effect. One human study from which conclusions could be drawn for the scientific substantiation of the claim showed no effect of Pacran® on defence against bacterial pathogens in the lower urinary tract. The Panel concludes that a cause and effect relationship has not been established between the consumption of Pacran® and defence against bacterial pathogens in the lower urinary tract.

  © European Food Safety Authority, 2014

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    AssociatedBlackshawsRdPharmacy @ Blackshaws Road Pharmacy on 15/11/2016 - 18:19

    Thanks for the Interesting citations! Yes, I think that's what Swisse are referring to when they mention PAcran. However, that's just one component of these tablets and of Cranberry as a whole. The Swisse cranberry tablets are made from desiccated whole berries. And there is actually pretty reasonable level of evidence that they are effective for UTIs.

    The following link is worth checking out if you're up for reading about the benefits of the Cranberry in natural health.
    https://www.ncbi.nlm.nih.gov/books/NBK92762/

    CRANBERRIES AND URINARY HEALTH

    The use of cranberry juice to prevent UTIs has a long history that was for many years supported mainly by anecdotal evidence. This is no longer the case: A body of scientific evidence has accumulated to support the use of cranberry in the maintenance of urinary tract health. Studies started appearing in the 1980s demonstrating the ability of cranberry juice to prevent adherence of E. coli bacteria to uroepithelial cells and other eukaryotic cells (Sobota 1984; Zafriri et al. 1989; Ofek et al. 1991). As type 1-fimbriated bacteria were susceptible to the fructose in citrus fruit juices as well, the effect on type P-fimbriated E. coli was observed to be specific to cranberry (Zafriri et al. 1989) and other Vaccinium. During the mid-1990s, a clinical study conducted by Avorn et al. (1994) on the female residents of a long-term care facility found a significant decrease in bacteria in the urine after 1 month of cranberry juice consumption. Since then, at least 15 clinical trials have evaluated the prophylactic effects of cranberry against urinary infections in a variety of populations. These studies are the subject of several detailed review articles (Howell 2002; Jepson and Craig 2007; Guay 2009).

    For many years, scientists and health practitioners believed that the antibacterial effects of cranberry juice were due to acidification of urine by hippuric acid produced by the metabolism of the quinic acid in cranberries (Blatherwick 1914; Bodel, Cotran, and Kass 1959). However, this claim was never substantiated. Studies correlating urinary pH with cranberry juice consumption show either no significant change in urine acidity or only a slight reduction in pH, which is insufficient to cause a bacteriostatic effect (Howell 2002). Researchers began to examine other possible mechanisms of action, which led to the discovery of bacterial antiadhesion properties (Sobota 1984). Studies on antiadherence of uropathogenic P-fimbriated E. coli (UPEC) responsible for the majority of UTIs found that a high-molecular-weight NDM from cranberry inhibited adhesion (Ofek et al. 1991). Bioassay-guided fractionation of cranberry targeting the active compounds found that cranberry tannins (Howell et al. 1998) blocked adherence of P-fimbriated E. coli to uroepithelial cells. The structures of these compounds were determined by nuclear magnetic resonance (NMR) analysis to be polyflavan-3-ol or PAC trimers composed of epicatechin units with an A-type linkage (Foo et al. 2000). The A-type linkage between monomer units (Figure 6.3), which features two linkage sites between the units (4β→8 and 2β→O→7 interflavanoid bonds), is a structural feature common to PACs from Vaccinium fruit. Proanthocyanidins from most other sources including cocoa and grape seeds contain primarily B-type (4β→8) linkages (Neto 2007), as shown in Figure 6.3. Cranberry PACs are primarily dimers, trimers, and larger oligomers of epicatechin units containing both A- and B-type linkages; therefore, their three-dimensional structures are diverse. Although cranberry NDM has been cited more in recent studies for its ability to inhibit cellular adhesion of H. pylori (Burger et al. 2000) and the development of lymphoma (Hochman et al. 2008), no information is available on the molecular structures of its components.

    The A-type linkage may hold the key to the antiadhesion activity of cranberry PACs. A comparison study of PACs isolated from several food sources, including cranberry, apple, grape, green tea, and chocolate, found that cranberry PACs prevented E. coli adhesion at the lowest concentration tested (60 μg/mL). Among the others, grape PACs showed antiadherence properties, but only at a much higher dose (1200 μg/mL), and the other food sources showed no activity (Howell et al. 2005). This study further found antiadhesion activity in human urine following consumption of cranberry juice cocktail, but not after consumption of other PAC sources. A randomized, double-blind, placebo-controlled crossover trial with 20 healthy volunteers was conducted to determine whether urine collected after cranberry consumption inhibited UPEC adherence to uroepithelial bladder cells. Subjects received a single dose of cranberry juice (750 or 250 mL mixed with 500 mL water) or placebo at night, and urine was collected in the morning and screened for antiadhesion against six UPEC strains. A significant and dose-dependent decrease in adherence of bacteria was observed in the urine of subjects who consumed cranberry (Di Martino et al. 2006).

    Several studies have examined the phenomenon of antibacterial adhesion by cranberry constituents in an attempt to better understand what happens at a submicroscopic level. Atomic force microscopy was used to measure the effect of cranberry juice exposure on bacterial surface characteristics and adhesion forces in a P-fimbriae-expressing E. coli (HB101pDC1) and a nonfimbriated strain. A decrease in fimbrial length was measured after a short exposure to cranberry juice, with a greater biopolymer density recorded near the cell wall (Liu et al. 2006). Adhesion forces decreased in proportion to cranberry juice concentration. No significant effect of cranberry on surface polymers or adhesive forces was observed with nonfimbriated E. coli. Later studies by this group showed that the effects of culturing the bacteria in cranberry juice or PAC extract on bacterial adhesion forces were reversible (Pinzon-Arango, Liu, and Camesano 2009). Interestingly, a more marked decrease in adhesive forces was observed with the juice cocktail than with the PAC fraction, suggesting that other components in the juice play a role in reducing bacterial adhesion. Another study found that morphological changes occurred when E. coli bacteria were grown in the presence of cranberry juice or PAC extract (Johnson et al. 2008). The authors observed a decrease in visible P-fimbriae and downregulation of gene expression associated with flagellar basal body rod and motor proteins.

    Clinical studies have demonstrated the efficacy of consuming cranberry juice or solids in UTI prevention for various populations, including women with recurrent UTIs (Walker et al. 1997; Stothers 2002; Bailey et al. 2007), pregnant women, (Wing et al. 2008), the elderly (Avorn et al. 1994; McMurdo et al. 2005; McMurdo et al. 2009), and children (Ferrara et al. 2009). A randomized, double-blind, placebo-controlled study of women aged 28–44 years with recurring UTIs using 400 mg of cranberry solids or placebo for 3 months found that 70% of the subjects had fewer UTIs while on cranberry (Walker et al. 1997). In a study of women aged 25–70 years with a history of high UTI recurrence (six or more in the previous year), it was found that consumption of 200 mg of concentrated cranberry extract standardized to 30% phenolics twice a day for 12 weeks prevented UTI recurrence in all subjects for the duration of the study (Bailey et al. 2007). A follow-up study of these subjects 2 years later found that those who continued to take cranberry remained free of infection. In pregnant women, for which asymptomatic bacteriuria can cause adverse perinatal outcomes if not detected and treated, consumption of 27% cranberry juice cocktail (240 mL, thrice daily) resulted in 57% reduction in asymptomatic bacteriuria and 41% reduction in UTI (Wing et al. 2008).

    In addition to Avorn’s landmark study on elderly women (Avorn et al. 1994), a randomized, double-blind, placebo-controlled study of hospitalized patients over 60 years of age found that the group consuming 25% cranberry juice cocktail (150 mL twice daily for 35 days or until discharge) had approximately half the occurrence of symptomatic UTI (McMurdo et al. 2005). A follow-up study by this group comparing treatment with 500 mg of cranberry extract to that with low doses of the antibiotic trimethoprim in older women found that both treatments reduced recurrent UTI. Trimethoprim treatment had only a limited advantage in this regard, and the cranberry group reported less adverse effects (McMurdo et al. 2009). Further clinical studies in such populations continue to provide information for health practitioners on the most effective forms and dosing regimens of cranberry against UTI.

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      Rayve on 16/11/2016 - 03:41

      +2

      Your supporting 'evidence' has been superseded. Later evidence and analysis now suggest NO benefit to cranberry products on urinary tract health.

      http://jamanetwork.com/journals/jama/article-abstract/257682…

      http://jamanetwork.com/journals/jama/article-abstract/257682…

      https://www.ncbi.nlm.nih.gov/pubmed/23076891

      The 'benefits' of cranberry is sometimes shown in small studies but in larger groups the effect is not statistically superior to placebo.

      Cranberry product manufacturer's, including juices and pills are currently denying these studies are correct, without actually producing evidence of why that is the case.

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        AssociatedBlackshawsRdPharmacy @ Blackshaws Road Pharmacy on 16/11/2016 - 15:45

        That's fair, thanks for sending the updated information Rayve. Much appreciated!
        With vitamins and complementary products most pharmacists will recommend them with a your-mileage-may-vary caveat.

      • 

        Rayve on 17/11/2016 - 00:42

        +1

        @BlackshawsRdPharmacy: Hey, thanks for being open to actual science - so many people, even health-care providers, are out to be salesmen first and patient advocates second.

        I myself always avoid chemists with 'homeopathic medicines' and huge displays of vitamins - they are simply cashing in on people's ignorance.

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        bargaino on 17/11/2016 - 09:51

        @Rayve:

        I myself always avoid chemists with 'homeopathic medicines' and huge displays of vitamins

        Where do you find any other sort? It shows why doctors are not allowed to sell medicine. Imagine how much snake-oil they'd be selling, especially in the corporate owned clinics.

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        Rayve on 17/11/2016 - 21:47

        @manic: There are a few around if you look with zero homeopathic water and smallish vitamin sections. It's a good test of the ethics of any pharmacist to ask them for what the science says about things like homeopathy - any that try to soft-sell the idea that 'magic water' works should not be trusted to be honest in any other areas of health for advice either.

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  DU99 on 15/11/2016 - 19:05

  +1

  Pickup allowed

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  bargaino on 26/11/2016 - 04:23

  http://www.abc.net.au/news/health/2016-11-24/cranberry-for-u…

  The researchers concluded cranberry supplements were no more effective than the placebo when it comes to preventing UTIs.